Anthony Watson and Mark Wilson were both selected to face Wales in the Six Nations clash in England at Twickenham on Saturday.
Bath Watson’s winger and back striker Wilson Sale will appear for the first time since the Rugby World Cup final defeat against South Africa last November.
Watson has recovered from a calf injury while Wilson recently returned to action after a knee problem.
Watson will start on the right wing where he replaces Jonathan Joseph, who leaves the 23 in total fifteen days after winning his 50th selection against Ireland.
An unspecified injury from Sam Underhill resulted in Wilson being chosen to the side flank after making only one sale start this season due to a knee problem.
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The return of Watson and Wilson are the only two changes from the team that beat Ireland 24-12 at Twickenham.
Watson was slated to start the Six Nations opening game against France, but suffered a setback in his recovery from an injury suffered in Bath earlier this month.
Wilson entered England for the first time last week after proving his ability to sell and is preferred over Lewis Ludlam, who missed a bench seat while Eddie Jones again opted for a split of six to two between attackers and backs.
England team to face Wales
E Daly (Buckwheat); A Watson (Bath), M Tuilagi (Leicester), O Farrell (Buckwheat, capt), J May (Leicester); G Ford (Leicester), B Youngs (Leicester); J Marler (Harlequins), J George (Saracens), K Sinckler (Harlequins), M Itoje (Saracens), G Kruis (Saracens), C Lawes (Northampton), M Wilson (Sale), T Curry (Sale).
Substitutes: L Cowan-Dickie (Exeter), E Genge (Leicester), W Stuart (Bath), J Launchbury (Wasps), C Ewels (Bath), B Earl (Saracens), W Heinz (Gloucester), H Slade (Exeter).