The NFL’s Week 1 schedule is packed full of can’t-miss games. Super Bowl champion Rams host the Bills on Thursday, Sept. 8 in the 2022 NFL Kickoff Game, while Russell Wilson takes on his former team, the Seahawks. On Sunday Night Football, arguably the league’s most popular team and the league’s most popular player will be on opposing sides as the Dallas Cowboys host Tom Brady and the Buccaneers. This is a rematch from last season’s Week 1, which Tampa won, and Caesars Sportsbook has the Bucs as 1.5-point favorites in the latest Week 1 NFL odds.
As for Wilson, he will finally face the 12th Man when the Broncos visit Seattle. Denver is a 6-point road favorite in the latest NFL spreads, but are you ready to place your Week 1 NFL bets on a Broncos team that hasn’t won in Seattle in 20 years? All of the NFL Week 1 lines are listed below, and SportsLine’s advanced computer model has all the NFL betting tips and predictions you need to make the best NFL Week 1 picks right now.
The model, which simulates every NFL game 10,000 times, has grown more than $7,500 for players to $100 on top NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on the NFL’s top picks that dates back to the 2017 season. Amazingly, he hasn’t missed a top-rated pick since Week 15 last season.
The model has also ranked in the top 10 on NFLPickWatch four of the last six years on NFL direct picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that time. Anyone who followed him is upstairs.
Now, he’s turned his attention to Caesars’ latest Week 1 NFL odds and locked in picks for every NFL game. Head here to see each choice.
Top NFL Week 1 Predictions
One of the best NFL Week 1 predictions recommended by the model: the Vikings (+2) cover against the Packers in more than 50% of simulations. Aaron Rodgers is one of many players bypassing preseason action, but that strategy led to horrific results in Week 1 of 2021. Rodgers had one of the worst games of his career without a touchdown and two interceptions in a neutral-court loss to the Saints. . The four-time MVP skipped preseason again this year and it could take him a while to find his groove.
The pattern projects another 100+ yard run from Vikings running back Dalvin Cook, while Kirk Cousins should balance Minnesota’s offense by throwing two touchdowns. The model acknowledges Rodgers’ struggles in Week 1, as well as the fact that star receiver Davante Adams is gone, and gives Cousins a bigger chance of passing for two touchdowns than Rodgers. Minnesota (+2) covers well over 50% of the simulations. See who else to support here.
Another of his Week 1 NFL predictions: the Colts (-8) cover the road against the Texans. Indy has won four straight games in this AFC South rivalry and the margin of victory has grown with each game. Last year, the Colts won 31-3 at home, then shut out the Texans 31-0 in Houston.
The Colts’ strength is their running game, led by Jonathan Taylor. The NFL running champion could have a head start on repeating that feat in Week 2 as he takes on Houston’s 31st-ranked running defense. Taylor rushed for 140 yards in both games against Houston last year, while also scoring two touchdowns in each. The model predicts Taylor will have more rushing yards than the entire Texans team as Indy wins by double digits. Indianapolis (-8) covers almost 60% of the time, and the model indicates that Over (44) hits in over 50% of simulations. See which other teams to pick here.
How to Make Week 1 NFL Picks
The model also made the call on who wins and covers in every other game on the NFL’s Week 1 schedule, and it calls for a Super Bowl contender to fall hard. You can only get every pick for every game on SportsLine.
So what NFL picks can you make with confidence? And which Super Bowl contender falls hard? Check out the latest NFL odds below, then visit SportsLine to see which teams are winning and covering the spread, all from a proven computer model that’s made over $7,500 since inception, and find out- the.
Week 1 NFL Odds, Lines, Spreads
Get all the NFL picks on SportsLine
Thursday, September 8
Rams to Bills (+2.5, 52)
Featured game | Los Angeles Rams vs. Buffalo Bills
Sunday September 11
Crows at Jets (+7, 44.5)
Featured Game | New York Jets vs. Baltimore Ravens
Browns vs. Panthers (-1.5, 41.5)
Featured Game | Carolina Panthers vs. Cleveland Browns
Colts at Texans (+8, 44)
Featured Game | Houston Texans vs. Indianapolis Colts
Jaguars at Commanders (-3.44)
Featured Game | Washington Commanders vs. Jacksonville Jaguars
Patriots at Dolphins (-2.5, 45)
Featured Game | Miami Dolphins vs. New England Patriots
Falcon Saints (+5.5, 42.5)
Featured Game | Atlanta Falcons vs. New Orleans Saints
Eagles to Lions (+4, 48.5)
Featured game | Detroit Lions vs. Philadelphia Eagles
Steelers at Bengals (-6.5, 44.5)
Featured game | Cincinnati Bengals vs. Pittsburgh Steelers
49ers at Bears (+7, 42)
Featured game | Chicago Bears vs. San Francisco 49ers
Packers at Vikings (+2, 48)
Featured game | Minnesota Vikings vs. Green Bay Packers
Chiefs at Cardinals (+3.5, 53)
Featured game | Arizona Cardinals vs. Kansas City Chiefs
Raiders at Chargers (-3.5, 52)
Featured game | Los Angeles Chargers vs. Las Vegas Raiders
Giants at Titans (-5.5, 44)
Featured game | Tennessee Titans vs. New York Giants
Buccaneers at Cowboys (+1.5, 50)
Featured game | Dallas Cowboys vs. Tampa Bay Buccaneers
Monday September 12
Broncos at Seahawks (+6, 41.5)
Featured Game | Seattle Seahawks vs. Denver Broncos