The San Francisco 49ers will host the Los Angeles Rams in an NFC West rivalry game on Monday Night Football. The two teams will meet for the first time since last season’s NFC Championship Game, which means plenty of tough decisions for your NFL DFS rosters. The NFL DFS player pool is full of stars like Cooper Kupp, Matthew Stafford, Deebo Samuel and George Kittle. Success in single game slates while playing NFL DFS tournaments, cash games and 50-50 on FanDuel and DraftKings is all about identifying the advantages. Which players have the best NFL DFS matchups for the Rams vs. 49ers and how should you differentiate your NFL DFS rosters? Before you make your NFL DFS picks for 49ers vs. Rams, be sure to check out the NFL DFS tips, strategy and player projections from SportsLine Fantasy daily expert Mike McClure.
McClure is a legendary DFS professional player with over $2 million in career earnings. His methodology has led to huge wins on FanDuel and DraftKings. He won two high-stakes tournaments on FanDuel in 2020 and recorded a pair of top 10s in tournaments with over 130,000 entrants on DraftKings. His rosters have also finished in the top 1% in over a dozen other tournaments.
It uses a powerful prediction model that simulates every instant NFL action, taking into account factors such as games, statistical trends, and injuries. This allows him to find the best DFS values which he only shares with SportsLine members.
In Week 3, McClure had Eagles quarterback Jalen Hurts as one of his top NFL DFS picks for FanDuel and DraftKings: The Result: Hurts had 340 passing yards, 20 rushing yards and three touchdowns passing, returning 30.6 points on DraftKings and 27.6 points on FanDuel. Everyone who had it in their lineups was on course for a huge day.
Now, McClure has turned his attention to the Rams vs. 49ers and locked in his top fantasy football daily picks. You can only see his picks and analysis on SportsLine.
Top NFL DFS picks for Rams vs. 49ers
One of McClure’s top NFL DFS picks for Monday Night Football is 49ers wide receiver Brandon Aiyuk. After a strong rookie season, Aiyuk was not heavily involved in San Francisco’s passing offense at the start of 2021, but returned to the coaching staff and Jimmy Garoppolo’s good graces and finished the year with even better numbers than it had in 2020.
Aiyuk has played at least 88% of snaps over the past 14 games and has 57 catches for 872 yards and five touchdowns in that span. He’s been targeted eight times in each of the past two games and caught eight passes for 102 yards and a scoring in those contests despite San Francisco’s offense not reaching 200 passing yards in a game. this season. However, the Rams rank 23rd in the NFL in pass defense, so this could be a spot for Aiyuk and the 49ers offense to spark their season.
McClure’s optimal NFL DFS strategy also includes lining up Rams wide receiver Cooper Kupp. After a season in which he caught 145 passes for 1,947 yards and 16 touchdowns, Kupp is once again posting sensational numbers. He caught 28 passes for 280 yards and three touchdowns and had a 20-yard rushing touchdown last week against the Cardinals.
Kupp was targeted 35 times in the first three weeks of the season to lead the league and also has the highest target share (34.7%) and instant share (98.3%) of all receivers in the league. NFL. He had 11 catches for 142 yards and two touchdowns in the NFC title game win over San Francisco last season and has passed the 100-yard mark in his last three games against the 49ers. You can see the rest of McClure’s NFL DFS tips here.
How to Create NFL DFS Lineups for the 49ers vs. the Rams
McClure is also targeting another undervalued option that could explode in numbers. This choice could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure’s NFL DFS picks, on SportsLine.
Who does Mike McClure include in his NFL DFS Optimal Lineups for Monday Night Football? And which under-the-radar player is a must-have? Visit SportsLine now to see the NFL DFS picks, rankings, tips and optimal stacks, all from a DFS expert who has made millions with his daily fantasy picks, and find out.