Saints vs. Cardinals odds, line, spread: Thursday Night Football picks, NFL predictions from compound model

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Thursday Night Football features the New Orleans Saints (2-4) and Arizona Cardinals (2-4) as they kick off the NFL’s Week 7 schedule. This NFC showdown involves two teams that badly need to win to gain momentum. Arizona is looking to snap a two-game skid. On the other side, New Orleans has lost four of its last five games. Cardinals wide receiver DeAndre Hopkins will return from a six-game suspension.

Kickoff is scheduled for 8:15 p.m. ET from State Farm Stadium. Arizona is favored by 2.5 points in Caesars Sportsbook’s latest Saints vs. Cardinals odds, and the over/under is 43.5. Before making Cardinals vs. Saints picks, you need to see NFL predictions and SportsLine’s computer simulation model betting tips.

The model, which simulates every NFL game 10,000 times, has grown nearly $7,000 for players to $100 on top NFL picks since its inception. The model enters Week 7 of the 2022 NFL season on an incredible 146-107 run on NFL’s top picks that dates back to the 2017 season.

The model has also ranked in the top 10 on NFLPickWatch four of the last six years on NFL direct picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that time. Anyone who followed him is upstairs.

Now the model has set its sights on Saints vs Cardinals and has just locked in its TNF picks and predictions. You can visit SportsLine now to see the model choices. Here are the NFL odds and betting lines for Cardinals vs. Saints:

  • Difference Saints vs Cardinals: Arizona -2.5
  • Saints vs. Cardinals over/under: 43.5 points
  • Silver line Saints vs Cardinals: New Orleans +122, Arizona -145
  • NO: Saints are 4-1 ATS in their last five games after a straight loss
  • ARI: Under bets are 5-0 in Cardinals’ last five games
  • Saints vs. Cardinals Picks: See the picks here

Featured Game | Arizona Cardinals vs. New Orleans Saints

Why Cardinals Can Cover

Arizona activated wide receiver DeAndre Hopkins to the 53-man roster after serving a six-game suspension. Hopkins has established a solid relationship with quarterback Kyler Murray and is looking to make an instant impact. The five-time Pro Bowl selection is dominant in the possession game with sticky hands and superb road running.

Hopkins possesses a post-catch burst with the ability to leap to snag disputed passes. He caught 14 touchdowns in his two seasons with Arizona. Rondale Moore is another dynamic weapon on offense. Moore rushes off the line with the speed to evade defenders. It can also cause damage to bezels and screens. The Purdue product has recorded more than 45 receptions in consecutive games. See which team to support here.

Why saints can cover

New Orleans has an extremely talented secondary that is inundated with difference makers. Safety Tyrann Mathieu is an athletically gifted defender at the back. Mathieu is constantly around the ball and plays with passion. The three-time Pro Bowl selection has the speed to crack the ball or deliver a big shot. He is third on the team in total tackles (29) with one interception.

Cornerback Paulson Adebo is a long-armed defender with ball-peddling skills. Adebo understands leverage well with active hands. The Stanford product boasts plenty of height (6-foot-1) and has the timing to deliver knockouts at the point of capture. Adebo has 20 total tackles and three pass deflections. See which team to support here.

How to Make Saints vs. Cardinals Choices

SportsLine’s model looks at the total, calling for a combined 48 points. It also indicates that one side of the spread has all the value. You can only get the model’s TNF picks from SportsLine.

So who wins Cardinals vs. Saints on Thursday Night Football? And which side of the spread has all the value? Visit SportsLine now to see which side of the Cardinals vs. Saints spread, all from the forward model that has risen nearly $7,000 on his NFL picks since 2017, and find out.



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