Real Madrid and Inter Milan will battle for Group A supremacy at the Bernabeu in the Champions League on Tuesday night.
Both teams have already qualified for the round of 16 of the competition, but first place and theoretically a more favorable round of 16 game is still up for grabs.
Los Blancos are currently top of Group A, two points clear of second-placed Inter but are battling several key injuries.
Both sides come into the game in formidable form, with Madrid on an eight-game winning streak while the Nerazzurri have taken five in a row.
Real Madrid v Inter Milan: Kick-off date and time
This Group D shock will take place on Tuesday, December 7.
It will be held at the Bernabeu in Madrid, Spain, with a UK kick-off time at 8 p.m.
Madrid won the second leg at San Siro 1-0 in September on Matchday 1, with Rodrygo scoring a game-winning goal in the last minute.
Real Madrid v Inter Milan: talkSPORT commentary
This match will be broadcast on talkSPORT 2 with coverage starting at 8 p.m. immediately following Manchester City’s clash with RB Leipzig.
Comments will come from Ian Danter and former Republic of Ireland striker David Connolly.
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Real Madrid v Inter Milan: team news
The hosts are grappling with a number of key injuries, with top marksman Karim Benzema being ruled out with a hamstring injury.
The Frenchman will join Dani Ceballos and Gareth Bale to miss the game against Milan ahead of the Madrid derby with Atletico next weekend.
The away team is deprived of Joaquin Correa, Aleksandar Kolarov, Andrea Ranocchia, Matteo Darmian and Stefan de Vrij.
Christian Eriksen is also unavailable as Inter’s only long-time absent.
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Real Madrid vs Inter Milan: what was said?
Carlo Ancelotti has expressed the importance of securing first place in the group tonight during his pre-match press conference.
He said: “I can’t say if we’re favorites or not. I can tell you that we will compete with all these teams because of the quality that we have.
“That’s it, so we have to wait and see because if you want to win this competition you have to play against the best teams in the world.
“If your goal is to go all the way in this competition, it doesn’t make a lot of difference whether you meet a strong team or not in the round of 16 or quarter-finals, you have to compete.
“I don’t know if we are going to win or not, but we are going to compete.”
Ancelotti added: “We play against a team that is playing very well and then we play for the first place, that’s important.
“Third, we play at home with our fans.
“These are three important reasons to watch the game which I think will be interesting.”