The first week of the NFL schedule features some intriguing storylines, but there’s no substitute for old-school division rivalry games. Between Sunday’s slate and Monday night’s game between Denver and Seattle, seven contests feature divisional opponents. One of the biggest lines in the NFL comes in an AFC South showdown between Indianapolis and Houston, where the Colts are eight-point favorites against the Texans in the latest Week 1 NFL odds on Caesars Sportsbook. The Cincinnati Bengals begin their quest to return to the Super Bowl as 6.5-point NFL favorites spread in their season opener against Pittsburgh. All of the NFL Week 1 lines are listed below, and SportsLine’s advanced computer model has all the NFL betting tips and predictions you need to make the best NFL Week 1 picks right now.
The model, which simulates every NFL game 10,000 times, has grown more than $7,500 for players to $100 on top NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on the NFL’s top picks that dates back to the 2017 season. Amazingly, he hasn’t missed a top-rated pick since Week 15 last season.
The model has also ranked in the top 10 on NFLPickWatch four of the last six years on NFL direct picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that time. Anyone who followed him is upstairs.
Now, he’s turned his attention to Caesars’ latest Week 1 NFL odds and locked in picks for every NFL game. Head here to see each choice.
Top NFL Week 1 Predictions
One of the best NFL Week 1 predictions recommended by the model: the Vikings (+2) cover against the Packers in more than 50% of simulations. Over the past six years, the Vikings are 4-2 ATS against Green Bay at home. The Packers finished last season 0-3 ATS in their last three road games, which included a trip to Minnesota.
For the past two years, cornerback Jaire Alexander has successfully bottled Minnesota wide receiver Justin Jefferson, but that might be a different story this season. Even though Jefferson is arguably already the best wide receiver in football, the third year is when most tend to burst. New Vikings head coach Kevin O’Connell joins the team after serving as the Rams’ offensive coordinator and helping orchestrate Cooper Kupp’s monster 2021 season, which included a seven-catch, 96-yard performance against Green Bay. See who else to support here.
Another of his Week 1 NFL predictions: the Colts (-8) cover the road against the Texans. Indianapolis had a disappointing end to its 2021-22 season, but it added quarterback Matt Ryan in the offseason and should be even better offensively this year. The Colts fire the NFL’s best running back, Jonathan Taylor, who will be hard for Houston to slow down.
SportsLine’s model has Taylor rushing for over 110 yards and scoring a touchdown, while Ryan is expected to be efficient with 250 passing yards and a pair of touchdowns. SportsLine’s model expects Indianapolis to do well offensively in Week 1, a key reason the Colts cover nearly 60 percent of simulations. See which other teams to pick here.
How to Make Week 1 NFL Picks
The model also made the call on who wins and covers in every other game on the NFL’s Week 1 schedule, and it calls for a Super Bowl contender to fall hard. You can only get every pick for every game on SportsLine.
So what NFL picks can you make with confidence? And which Super Bowl contender falls hard? Check out the latest NFL odds below, then visit SportsLine to see which teams are winning and covering the spread, all from a proven computer model that’s made over $7,500 since inception, and find out- the.
Week 1 NFL Odds, Lines, Spreads
Get all the NFL picks on SportsLine
Thursday, September 8
Rams to Bills (+2.5, 53)
Featured Game | Los Angeles Rams vs. Buffalo Bills
Sunday September 11
Crows at Jets (+7, 44.5)
Featured Game | New York Jets vs. Baltimore Ravens
Browns vs. Panthers (-1.5, 41.5)
Featured game | Carolina Panthers vs. Cleveland Browns
Colts at Texans (+8, 44)
Featured game | Houston Texans vs. Indianapolis Colts
Jaguars at Commanders (-3.44)
Featured game | Washington Commanders vs. Jacksonville Jaguars
Patriots at Dolphins (-2.5, 45)
Featured game | Miami Dolphins vs. New England Patriots
Falcon Saints (+5.5, 42.5)
Featured game | Atlanta Falcons vs. New Orleans Saints
Eagles to Lions (+4, 48.5)
Featured game | Detroit Lions vs. Philadelphia Eagles
Steelers at Bengals (-6.5, 44.5)
Featured game | Cincinnati Bengals vs. Pittsburgh Steelers
49ers at Bears (+7, 42)
Featured game | Chicago Bears vs. San Francisco 49ers
Packers at Vikings (+2, 48)
Featured Game | Minnesota Vikings vs. Green Bay Packers
Chiefs at Cardinals (+3.5, 53)
Featured game | Arizona Cardinals vs. Kansas City Chiefs
Raiders at Chargers (-3.5, 52)
Featured game | Los Angeles Chargers vs. Las Vegas Raiders
Giants at Titans (-5.5, 44)
Featured game | Tennessee Titans vs. New York Giants
Buccaneers at Cowboys (+1.5, 50)
Featured game | Dallas Cowboys vs. Tampa Bay Buccaneers
Monday September 12
Broncos at Seahawks (+6, 41.5)
Featured game | Seattle Seahawks vs. Denver Broncos
