Aaron Wan-Bissaka is expected to be ruled out for up to two months, according to talkSPORT.
The defender suffered a hamstring injury after being substituted in Saturday’s 3-1 home defeat to Brighton.
Now, the Red Devils have confirmed in a statement on their website that the right-back is facing “a period of inactivity”.
Wan-Bissaka’s setback is another blow to Man United’s defensive options.
Centre-back Raphael Varane missed the defeats against Arsenal and Brighton through injury, while left-backs Luke Shaw and Tyrell Malacia were also sidelined.
Tom Heaton, Kobbie Mainoo, Sofyan Amrabat, Mason Mount and Amad Diallo are also absent, while Jadon Sancho and Antony are unavailable due to off-field issues.
Diogo Dalot started at right-back against the Seagulls, with Wan-Bissaka coming on as a late replacement.
But the 25-year-old had started all four matches in that position before Saturday, providing the assist for the winning goal against Wolves on the opening weekend.
Wan-Bissaka will miss Man United’s Champions League opener against Bayern Munich, as well as upcoming Premier League matches against Burnley, Crystal Palace and Brentford.
He will also be absent for the Carabao Cup match against Palace and the Champions League group match against Galatasaray.
Man United’s statement regarding Wan-Bissaka’s injury read: “Aaron Wan-Bissaka is sidelined for a period after picking up an injury during the closing stages of Saturday’s match against Brighton & Hove Albion.
The right-back came on in the 85th minute, having started the match on the bench after battling illness during the week.
“Further assessments will be needed to determine the duration of Wan-Bissaka’s absence, but early indications suggest it will take several weeks.”
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