The San Francisco 49ers will look for their 13th straight regular season victory when they begin Week 3 of the 2023 NFL schedule with their home opener against the New York Giants on Thursday Night Football. San Francisco (2-0) finished the 2022 regular season with 10 straight wins and opened the new year with road victories over the Steelers and Los Angeles Rams, scoring 30 points in both contests. New York (1-1) avoided an 0-2 start by staging the franchise’s biggest comeback of the Super Bowl era to earn a 31-28 win at Arizona, but lost running back Saquon Barkley for three weeks due to a sprained ankle. .
Kickoff from Levi’s Stadium is scheduled for 8:15 p.m. ET. San Francisco is a 10.5-point favorite in the latest Giants vs. 49ers odds, while the over/under for total points scored is 45. Before making any 49ers vs. Giants picks, you should check the NFL predictions and SportsLine betting tips. Advanced computer model.
The model, which simulates every NFL game 10,000 times, has increased by more than $7,000 for $100 players among the NFL’s top-rated picks since its inception. The model enters Week 3 of the 2023 NFL season with an incredible 164-117 streak on top-rated NFL picks dating back to the 2017 season. He is also on an 18-9 record among highest-rated picks in the NFL since Week 7 of last season.
The model has also ranked in the top 10 on NFLPickWatch four of the last six years on straight NFL picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who followed him is at the top.
Now the model has set its sights on the 49ers vs. Giants and has just locked in its Thursday Night Football picks and predictions. You can now head over to SportsLine to see the model’s choices. Here are several NFL odds and betting lines for the Giants vs. 49ers:
- Giants vs. 49ers spread: San Francisco -10.5
- Giants vs. 49ers over/under: 45 points
- Money line Giants vs. 49ers: San Francisco -547, New York +401
- SF: 49ers are 14-8 ATS, including playoffs, since the start of the 2022 season
- NYG: Giants are 0-2 ATS this year after going 14-5 in 2022, including playoffs
- Giants vs. 49ers picks: See the picks on SportsLine
Why the 49ers can cover
San Francisco trailed Los Angeles late in the second quarter last Sunday before outscoring the Rams 20-6 en route to the victory. Christian McCaffrey had another strong effort on the ground, as he carried 20 times for 116 yards and a touchdown. Since last year, the 27-year-old has recorded five 100-yard rushing performances in his last seven regular season games and has run for a touchdown in six of them.
McCaffrey, who eclipsed the 1,000-yard mark for the third time in his career last season, leads the NFL in rushing this year with 268 yards. Including the playoffs, he has found his way to the end zone in 13 of his 16 games since being acquired from Carolina last October. During that span, he passed for 10 touchdowns and completed five scoring passes. He has recorded 40 rushing touchdowns and 22 receptions since joining the NFL in 2017, making him the fifth player in the Super Bowl era with at least 40 and 20 respectively in his first seven seasons . Find out which team to choose here.
Why the Giants can cover
New York was outscored 60-0 through its first six quarters of the season and fell behind 28-7 late in the third quarter against Arizona before coming back to life. The Giants scored 24 unanswered runs to tie the largest comeback in franchise history, most recently achieved in 1949 against the Chicago Cardinals. Quarterback Daniel Jones completed 81 percent of his attempts in the second half and finished with 321 passing yards and two touchdowns while rushing for 59 yards and a score.
The 26-year-old became the first player in Giants history to record 250 passing yards, 50 rushing yards, two touchdown passes and a rushing score in the same game, all of which he recorded in second half. He was 26 of 37 in the win and may have found a No. 1 target in wide receiver Jalin Hyatt. A third-round pick in this year’s NFL draft, the 21-year-old rookie’s first career reception totaled 58 yards on the first play of the second half, and he had a 31-yard catch on the fourth quarter that led to New York. York’s tying touchdown. Find out which team to choose here.
How to make 49ers vs. Giants picks on TNF
SportsLine’s model leans toward the point total, calling for 45 combined points. The model also indicates that one side of the spread is cashed in almost 60% of simulations. You can only see the model’s TNF picks at SportsLine.
So who does the 49ers win against the Giants on Thursday Night Football, and which side of the spread concedes nearly 60% of the time? Visit SportsLine now to see which side of the 49ers vs. Giants spread you should jump to, all from the model on a 164-117 result on NFL picks, and find out.