Chiefs vs 49ers odds, line, spread, prediction: 2022 NFL picks, Week 7 best bets by model on 146-107 run

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The San Francisco 49ers (3-3) host the Kansas City Chiefs (4-2) in an interconference contest on Sunday in what could be a game of chess. Kansas City has one of the best offenses in the league, ranking sixth in total offense (382.3). Meanwhile, San Francisco has a top-notch defensive squad. The 49ers lead the NFL in total yards allowed (255.8) and were just traded for star running back Christian McCaffrey.

Kickoff is scheduled for 4:25 p.m. ET. Kansas City is a one-point favorite in Caesars Sportsbook’s latest Chiefs vs. 49ers odds, and the over/under is 49. SportsLine Projection Model betting.

The model, which simulates every NFL game 10,000 times, has grown nearly $7,000 for players to $100 on top NFL picks since its inception. The model enters Week 7 of the 2022 NFL season on an incredible 146-107 run on NFL’s top picks that dates back to the 2017 season.

The model has also ranked in the top 10 on NFLPickWatch four of the last six years on NFL direct picks and has beaten more than 94% of CBS Sports Football Pick’em players four times during that time. Anyone who followed him is upstairs.

Now the model has set his sights on Chiefs vs Niners, and just locked in his NFL picks and predictions. You can visit SportsLine now to see the model choices. Here are the NFL odds and betting lines for the Niners vs. Chiefs:

  • Difference Chiefs vs. 49ers: Kansas City -1
  • Chiefs vs. 49ers over/under: 49 points
  • Money line Chiefs vs 49ers: San Francisco +105, Kansas City -125
  • KC: Over bets are 6-1 in Chiefs’ last seven road games
  • SF: 49ers are 6-0 ATS against teams with winning record
  • Chiefs pick vs. 49ers: See the picks on SportsLine

Featured game | San Francisco 49ers vs. Kansas City Chiefs

Why the Chiefs can cover

Tight end Travis Kelce is a dynamic all-court weapon. Kelce possesses a rare combination of size (6-foot-5, 250 pounds) and speed. He is a match nightmare and has a solid road tree. The seven-time Pro Bowler serves as the weapon of choice in the offense and is a strong red zone target. Kelce is tied for sixth in receptions (41), 10th in receiving yards (455) and first in touchdowns (seven).

JuJu Smith-Schuster is a safe receiver for Kansas City. Smith-Schuster isn’t afraid to run in midfield and provide opportunities for the YAC. The USC product has a large and powerful frame that allows him to box defenders. He is second on the team in catches (27) and receiving yards (370). Last week he had five receptions for 113 yards and a score. See which team to support here.

Why the 49ers can cover

While the Niners are hoping Christian McCaffrey can give them a boost on offense, San Francisco has already shown the ability to play solid defense. The 49ers play with a combination of discipline, aggression and speed. They force their opponents into difficult situations and thrive on it. The unit is first in the league in total defense (255.8) and second in passing yards allowed (168.3) and rushing yards allowed (87.5).

Linebackers Dre Greenlaw and Fred Warner form a dynamic duo in midfield. Greenlaw is an athletic, fast point guard who is instinctive against the run. The Arkansas product leads the team in total tackles (55) with three tackles for loss. Warner brings another nimble difference maker who can play very well against the pass and the run. The 2020 Pro Bowl selection is second on the team in total saves (44) with two pass deflections and 0.5 sacks. See which team to support here.

How to make choices between 49ers and Chiefs

SportsLine’s model looks at total points. In fact, he claims 47 points in total. It also indicates that one side of the spread cashes in well over 50% of the time. You can only see the model choice on SportsLine.

So who wins the Niners against the Chiefs? And which side of the spread cashes well more than 50% of the time? Visit SportsLine now to see which way the 49ers vs. Chiefs have spread, all from the advanced model that costs nearly $7,000 on NFL picks, and find out.



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