Jimmy Garoppolo and the San Francisco 49ers (6-4) look to stay warm as they host Andy Dalton and the New Orleans Saints (4-7) in an NFL Week 12 game at the Levi’s Stadium on Sunday. The Niners are riding a three-game winning streak after knocking out the Arizona Cardinals at Monday Night Football in Mexico City. Meanwhile, the Saints are looking to build on their 27-20 win over the Los Angeles Rams in Week 11. New Orleans is 4-7 ATS, while San Francisco has a 5-5 ATS in 2022.
Kickoff is at 4:25 p.m. ET. San Francisco is favored by 9 runs in Caesars Sportsbook’s latest 49ers vs. Saints odds, and the over/under is set at 43. Before we get into the Saints vs. 49ers picks, you need to see NFL predictions and betting tips of the proven computer simulation model at SportsLine.
The model, which simulates every NFL game 10,000 times, has grown more than $7,000 for players to $100 on top NFL picks since its inception. The model enters week 12 of the 2022 NFL season on an incredible 155-109 run on the NFL’s top picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on NFL Direct Picks and has beaten over 94% of CBS Sports Football Pick’em players four times during that time. Anyone who followed him is upstairs.
Now, the model has set his sights on the 49ers against the Saints and has just locked down his picks and NFL Week 12 predictions. You can head over to SportsLine now to see the model choices. Here are several NFL odds and betting lines for Saints vs 49ers:
- Difference 49ers vs. Saints: 49ers -9
- 49ers vs. Saints over/under: 43 points
- 49ers vs. Saints silver line: San Francisco -455, New Orleans +345
- 49ers vs. Saints picks: See the picks here
Featured Game | San Francisco 49ers vs. New Orleans Saints
What you need to know about the 49ers
The 49ers won their game against the Arizona Cardinals last Monday by a conclusive score of 38-10. The game was nearly over by the end of the third, at which point San Francisco had established a 31-10 advantage. San Francisco QB Jimmy Garoppolo threw it passing for four touchdowns and 228 yards on 29 attempts.
The 49ers are 3-1 since acquiring All-Pro running back Christian McCaffrey and are quickly emerging as one of the top contenders in a wide-open NFC run. Already one of the best defensive teams in the NFL, the Niners now boast one of the most balanced and hardest defending offenses in the league with McCaffrey, Elijah Mitchell, Deebo Samuel, Brandon Aiyuk and George Kittle all at Garoppolo’s layout.
What you need to know about saints
Meanwhile, New Orleans picked up a 27-20 victory over the Los Angeles Rams last Sunday. Dalton had three touchdowns and 260 yards on 25 attempts. Dalton’s 53-yard touchdown in the middle of WR Chris Olave in the third quarter was one of the most memorable moments of the afternoon.
The Saints could get a much-needed boost this week with cornerback Marshon Lattimore (abdomen), cornerback Bradley Roby, defensive end Cameron Jordan (eye), defensive end Marcus Davenport (calf), left guard Andrus Peat (triceps), left tackle James Hurst (concussion) and running back Mark Ingram (knee) are all back in practice this week. They are all listed as questionable, with several expected to play on Sunday.
How to make 49ers vs. Saints picks
The model has simulated Saints vs. 49ers 10,000 times and the results are in. The model looks at point totals, and it also generated a point pick that hits in over 50% of simulations. You can only see the model choice on SportsLine.
So who wins the Saints against the 49ers? And which side of the spread hits well over 50% of the time? Visit SportsLine now to find out which side of the 49ers vs. Saints spread you should be on everywhere, all from the model on a 155-109 roll on his top-rated NFL picks, and find out.